Clinical and dermoscopic features of nevi in patients with psoriasis

Abstract - 663 PDF - 407
Ilina Natalia Glebovna, Krinitsuna Yulia Mihailovna, Taganov Aleksey Viktorovich, Tulupov Andrey Aleksandrovich, Kolesnikova Irina Stanislavovna, Yudkin Dmitry Vladimirovich, Sergeeva Irina Gennadievna

Abstract


The aim of the present study is to display the clinical and dermoscopic features of melanocytic nevi of more than 5 mm in diameter in psoriasis patients. A total of 32 patients with psoriasis (21 male, 11 female; average age 37.4) formed the first study group. In 22 patients (68.8%), melanocytic nevi of 5 mm in diameter and bigger (total of 68 nevi) were clinically found. For a randomized trial, 100 people (21 male, 79 female; average age 27.8) without psoriasis were invited to form the second study group. Only 37 of them had nevi ≥5 mm in diameter (total of 60 nevi). Complete questionnaire, full body photometric skin examination, dermoscopy examination on the dermatoscope HEINE MINI 10X with 70% ethyl alcohol immersion, skin type identification according to the Fitzpatrick classification, and nevi assessment according to ABCD and ABC rules were obtained for all recruited people. Our study showed that patients with psoriasis are more susceptible to melanocytic nevi of >5 mm in diameter (68.8%), while the result for the second group was 37%. As for nevi of dysplastic criteria, we found 32% in psoriasis patients vs. 42% in the monitoring group. Moreover, we should bear in mind the influencing factors of skin phototype II and artificial insolation (e.g., tanning, PUVA (Psoralen and ultraviolet A), and narrowband phototherapy 311 nm) obtained by the patients from the first group.


Keywords


Melanocytic nevi; psoriasis; dermoscopy; melanoma

Full Text:

PDF

References


Rezze GG, Leon A, Duprat J. Nevo displásico (nevo atípico) (Portugese) [Dysplastic nevus (atypical nevus)]. An Bras Dermatol 2010; 85(6): 863–871. doi: 10.1590/ S0365-05962010000600013.

Cyr PR. Atypical moles. Am Fam Physician 2008; 78(6): 735–740.

Csoma Z, Erdei Z, Bartusek D, Dosa-Racz E, Dobozy A, et al. The prevalence on melanocytic naevi among schoolchildren in South Hungary. J Eur Acad Dermatol Venereol 2008; 22(12): 1412–1422. doi: 10.1111/j.1468- 3083.2008.02887.x.

Narayanan DL, Saladi RN, Fox JL. Review: Ultraviolet radiation and skin cancer. Int J Dermatol 2010; 49(9): 978–986. doi: 10.1111/j.1365-4632.2010.04474.x.

Wong T, Hsu L, Liao W. Phototherapy in psoriasis: A review of mechanisms of action. J Cutan Med Surg 2013; 17(1): 6–12. doi: 10.2310/7750.2012.11124.

Gross RL, Schwartzman-Morris JS, Krathen M, Reed G, Chang H, et al. A Comparison of Malignancy Incidence among Psoriatic and Rheumatoid Arthritis Patients in a Large US Cohort Arthritis Rheumatol. 2014 Jun; 66(6): 1472–1481. doi: 10.1002/art.38385

Beyaert R, Beaugerie L, Van Assche G, Brochez L, Renauld JC, et al. Cancer risk in immune-mediated in-flammatory diseases (IMID). Mol Cancer 2013; 12(1): 98. doi: 10.1186/1476-4598-12-98.

Pérez Ramírez S, Parra V, Avilés Izquierdo JA, Vicario JL, Martín M, et al. Metastatic melanoma with spontaneous regression, psoriasis and HLA-Cw6: Case report and a hypothesis to explore. Tumori 2014; 100(4): 144e–147e. doi: 10.1700/1636.17932.

Marghoob AA, Scope A. The complexity of diagnosing melanoma. J Invest Dermatol 2009; 129(1): 11–13. doi: 10.1038/jid.2008.388.

Goodson AG, Grossman D. Strategies for early melanoma detection: Approaches to the patient with nevi. J Am Acad Dermatol 2009; 60(5): 719–735. doi: 10.1016/ j.jaad.2008.10.065.

Mancebo SE, Hu JY, Wang SQ. Sunscreens: A review of health benefits, regulations, and controversies. Dermatol Clin 2014; 32(3): 427–438. doi: 10.1016/j.det.2014.03.011.

Goldstein AM, Tucker MA. Dysplastic nevi and mel-anoma. Cancer Epidemiol Biomarkers Prev 2013; 22(4): 528–532. doi: 10.1158/1055-9965.EPI-12-1346.

Dediol I, Bulat V, Živković MV, Marković BM, Šitum M. Dysplastic nevus–Risk factor or disguise for melanoma. Coll Antropol 2011; 35 (Suppl 2): 311–313.

Kittler H, Tschandl P. Dysplastic nevus: Why this term should be abandoned in dermatoscopy. Dermatol Clin 2013; 31(4): 579–588. doi: 10.1016/j.det.2013.06.009.

Hurwitz RM, Tavel ME. The mythical concept and unto-ward consequences of a diagnosis of dysplastic nevus: An overdue tribute to A. Bernard Ackerman, MD. Dermatol Pract Concept 2015; 5(1): 31–34. doi: 10.5826/dpc.0501a05.

Wollina U, Schaarschmidt H, Henkel U, Roth H, Barta U, et al. (German) [A combination of psoriasis vulgaris and nevus cell nevus–Clinical, histopathologic and histoche-mical findings]. Z Hautkr 1990; 65(4): 381–322, 385– 387.

Balato N, Di Costanza L, Balato A, Patruno C, Scalvenzi M, et al. Psoriasis and melanocytic naevi: Does the first confer a protective role against melanocyte progres-sion to naevi? Br J Dermatol 2011; 164(6): 1262–1270. doi: 10.1111/j.1365-2133.2011.10271.x.

Di Cesare A, Riitano A, Suppa M, Fidanza R, Zangrilli A, et al. Frequency of melanocytic nevi in psoriatic patients is related to treatment and not to disease severity. J Am Acad Dermatol 2013; 69(6): 947–953. doi: 10.1016/j.jaad. 2013.08.017.

Koseoglu G, Akay BN, Kucuksahin O, Erdem C. Dermo-scopic changes in melanocytic nevi in patients receiving immunosuppressive and biologic treatments: Results of a prospective case-control study. J Am Acad Dermatol 2015; 73(4): 623–629. doi: 10.1016/j.jaad.2015.07.013.

Kowalzick L, Eickenscheidt L, Komar M, Schaarschmidt E. Prolongierte Psoriasistherapie mit TNF-α-Anta¬go¬nisten. Entwicklung des malignen Melanoms (German) [Long term treatment of psoriasis with TNF-alpha antagonists. Occurrence of malignant melanoma]. Hautarzt 2009; 60(8): 655–657. doi: 10.1007/s00105-008-1695-8.

Hofbauer G. Phototherapie und karzinogenese (German) [Phototherapy and carcinogenesis]. Hautarzt 2013; 64(5): 349–353. doi: 10.1007/s00105-013-2587-0.

Maiorino A, De Simone C, Perino F, Caldarola G, Peris K. Melanoma and non-melanoma skin cancer in psoriatic patients treated with high-dose phototherapy. J Dermatolog Treat 2016; 27(5): 443–447. doi: 10.3109/0954¬6-634.2015.1133882.

Pouplard C, Brenaut E, Horreau C, Barnetche T, Misery L, et al. Risk of cancer in psoriasis: A systematic review and meta-analysis of epidemiological studies. J Eur Acad Dermatol Venereol 2013; 27(Suppl 3): 36–46. doi: 10.1111/jdv.12165.

Richard MA, Barnetche T, Horreau C, Brenaut E, Pouplard C, et al. Psoriasis, cardiovascular events, cancer risk and alcohol use: Evidence-based recomme¬ndati-ons based on systematic review and expert opinion. J Eur Acad Dermatol Venereol 2013; 27(Suppl 3): 2–11. doi: 10.1111/jdv.12162.


Refbacks

  • There are currently no refbacks.