Laugier-Hunziker syndrome: A diagnostic dilemma?

  • Shamma Aboobacker KMCT Medical College and hospital
  • Kaliaperumal Karthikeyan Sri Manakula Vinayagar medical college and hospital
  • Shiraz Naha KMCT medical college and hospital
  • Laxmi V Nair KMCT medical college and hospital
  • Aneesh Bava KMCT medical college and hospital
  • Beegum Sherjeena KMCT medical college and hospital
DOI: https://doi.org/10.18282/jsd.v2.i3.120
Keywords: Laugier-Hunziker syndrome, Hutchinson’s sign

Abstract

Laugier-Hunziker syndrome (LHS) is an idiopathic hypermelanotic condition that displays a characteristic pattern of mucosal, acral and nail pigmentation. The etiology is unknown, while its benign nature has been repeatedly highlighted. Owing to close resemblance to more serious disorders, it is necessary that the diagnostic features are understood; and thereby we report two sporadic cases of LHS in different age groups displaying varied presentations with identifiable features.

References

Yago K, Tanaka Y, Asanami S. Laugier-Hunziker-Baran syndrome. Oral Surg Oral Med Oral Patho Endod 2008; 106(2): e20–e25. doi: 10.1016/j.tripleo.2008.03.037.

Began D, Mirowski G. Perioral and avral lentigines in an African American man. Arch Dermatol 2000; 136 (3): 419, 422.

Ma DL, Vano-Galvan S. Hyperpigmentation in Laugier-Hunziker syndrome. CMAJ 2011; 183(12):1402. doi: 10.1503/cmaj.110211

Wang WM, Wang X, Duan N, Jiang HL, Huang XF. Laugier-Hunziker syndrome: A report of three cases and literature review. Int J Oral Sci 2012; 4(4): 226–230. doi: 10.1038/ijos.2012.60.

Laugier P, Hunziker N. Pigmentation mélanique lenticulaire, essentielle, de la muqueuse jugale et des lèvres. Arch Beig Dermatol Syphiligr 1970; 26(3): 391–399.

Nayak RS, Kotrashetti VS, Hosmani JV. Laugier-Hunziker syndrome. J Oral Maxillofac Pathol 2012; 16(2): 245–250. doi: 10.4103/0973-029X.99079.

Lampe AK, Hampton PJ, Woodford-Richens K, Tomlinson I, Lawrence CM, et al. Laugier-Hunziker syndrome: An important differential diagnosis for Peutz-Jeghers syndrome. J Med Genet 2003; 40(6): e77. doi: 10.1136/jmg.40.6.e77.

Montebugnoli L, Grelli I, Cervellati F, Misciali C, Raone B. Laugier-Hunziker syndrome: An uncommon cause of oral pigmentation and a review of the literature. Int J Dent 2010; 2010(2010): Article ID 525404. doi: 10.1155/2010/525404.

Asati DP, Tiwari S. Laugier-Hunziker syndrome. Indian J Dermatol Venereol Leprol 2011; 77(4): 536–537. doi: 10.4103/0378-6323.82422.

Jabbari A, Gonzalez ME, Franks AG Jr., Sanchez M. Laugier Hunziker syndrome. Dermatol Online J 2010; 16(11): 23.

Gerbig AW, Hunziker T. Idiopathic lenticular mucocutaneous pigmentation of Laugier-Hunziker syndrome with atypical features. Arch Dermatol 1996; 132(7): 844–845. doi: 10.1001/archderm.1996.03890310136032.

Sachdeva S, Sachdeva S, Kapoor P. Laugier-Hunziker syndrome: A rare cause of oral and acral pigmentation. J Cutan Aesthet Surg 2011; 4(1): 58–60. doi: 10.4103/0974-2077.79199.

Lee MS, Chiu HC, Wang LF. Laugier-Hunziker syndrome. Dermatol Sinica 2006; 24(3): 209–212.

Moore RT, Chae KAM, Rhodes AR. Laugier and Hunziker pigmentation: A lentiginous proliferation of melanocytes. J Am Acad Dermatol 2004; 50(5): S70–74. doi: 10.1016/j.jaad.2003.09.016.

Ergun S, Saruhanoglu A, Migliari DA, Maden I, Tanyeri H. Refractory pigmentation associated with Laugier-Hunziker syndrome following Er:YAG Laser treatment. Case Rep in Dent 2013; 2013(2013): Article ID 561040. doi: 10.1155/2013/561040.

Published
2020-05-09
Issue
Vol. 5 No. 2 (2020)
Section
Case Reports

Copyright (c) 2020 Aboobacker S, et al.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Author(s) shall retain the copyright of their work and grant the Journal/Publisher rights for the first publication with the work concurrently licensed under the Creative Commons Attribution-Noncommercial 4.0 International License

Under this license, author(s) will allow third parties to download, reuse, reprint, modify, distribute and/or copy the content under the condition that the authors are given credit and that the work is not used for commercial purposes. No permission is required from the authors or the publisher.

This broad license intends to facilitate free access, as well as the unrestricted use of original works of all types. This ensures that the published work is freely and openly available in perpetuity.