An update in the management of malignant melanoma

  • Jayabal Pandiaraja SRM Medical College Hospital & Research Centre
Keywords: malignant melanoma, recent update, management


Malignant melanoma is one of the most dangerous forms of cutaneous malignancies. It is classified as cutaneous melanoma and non-cu­­taneous melanoma based on the location of the lesion. Ultraviolet (UV) radiation exposure is a predisposing factor for cutaneous melanoma, although in other forms such as mucous and anorectal malignant melanomas, ultraviolet radiation does not play a significant role. Human papilloma virus and human retroviral infections are commonly associated with non-cutaneous melanomas.


Javabal P, Subramanian V. An unusual case of desmo-plastic malignant melanoma. J Cutan Aesthet Surg 2015; 8(1): 60–63. doi: 10.4103/0974-2077.155093.

Jayabal P. Uncommon presentation of anorectal melanoma. Clin Cancer Invest J 2015; 4(5): 662–664. doi: 10.4103/2278-0513.162252.

Rivera A, Nan H, Li T, Qureshi A, Cho E. Alcohol intake and risk of incident melanoma: A pooled analysis of three prospective studies in the United States. Cancer Epidemiol Biomark Prev 2016; 25(12): 1550–1558. doi: 10.1158/1055-9965.EPI-16-0303.

Bolerazska B, Rabajdova M, Spakova I, Marekova M. Current knowledge on the active form of vitamin D syn-thesized in the skin and its effects on malignant melanoma. Neoplasma 2016; 64(1). In Press. doi: 10.4149/neo_ 2017_101.

Jaworek-Korjakowska J. Computer-aided diagnosis of micro-malignant melanoma lesions applying support vector machines. Biomed Res Int 2016; 2016: 4381972. doi: 10.1155/2016/4381972.

Li Y, Cheng HS, Chng WJ, Tergaonkar V. Activation of mutant TERT promoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomas. Proc Natl Acad Sci U S A 2016; 113(50): 14402–14407. doi: 10.1073/pnas.1611106113.

Melamed RD, Aydin IT, Rajan GS, Phelps R, Silvers DN, et al. Genomic characterization of dysplastic nevi unveils implications for diagnosis of melanoma. J Invest Dermatol 2016. In Press. doi: 10.1016/j.jid.2016.11.017.

Wurth L, Papasaikas P, Olmeda D, Bley N, Calvo GT, et al. UNR/CSDE1 drives a post-transcriptional program to promote melanoma invasion and metastasis. Cancer Cell 2016; 30(5): 694–707. doi: 10.1016/j.ccell.2016.10.004.

Bosserhoff AK, Schneider N, Ellmann L, Heinzerling L, Kuphal S. The Neurotrophin Neuritin1 (cpg15) is involved in melanoma migration, attachment independent growth, and vascular mimicry. Oncotarget 2016. In Press. doi: 10.18632/oncotarget.13585.

Coati I, Miotto S, Zanetti I, Alaibac M. Toll-like receptors and cutaneous melanoma (Review). Oncol Lett 2016; 12(5): 3655–3661. doi: 10.3892/ol.2016.5166.

Boland MR, Prichard RS, Bass GA, Al-Hilli Z, Levendale A, et al. Malignant melanoma: Factors affecting the surgical interval from excision biopsy to definitive surgical management. Ir J Med Sci. 2015; 184(2): 511–515.

Atkinson V, Long GV, Menzies AM, McArthur G, Carlino MS, et al. Optimizing combination dabrafenib and trametinib therapy in BRAF mutation-positive advanced melanoma patients: Guidelines from Australian melanoma medical oncologists. Asia Pac J Clin Oncol 2016; 12 (Suppl S7): 5–12. doi: 10.1111/ajco.12656.

Khosravi S, Martinka M, Zhou Y, Ong CJ. Prognostic significance of the expression of nuclear eukaryotic translation initiation factor 5A2 in human melanoma. Oncol Lett 2016; 12(5): 3089–3100. doi: 10.3892/ol. 2016.5057.

Dowling P, Moran B, McAuley E, Meleady P, Henry M, et al. Quantitative label-free mass spectrometry analysis of formalin-fixed, paraffin-embedded tissue representing the invasive cutaneous malignant melanoma proteome. Oncol Lett 2016; 12(5): 3296–3304. doi: 10.3892/ol. 2016.5101.

Xie FY, Fan H, Yang L, Jiang ZG, Meng RS, et al. Melanoma classification on dermoscopy images using a neural network ensemble model. IEEE Trans Med Imaging 2016. In Press. doi: 10.1109/TMI.2016.2633551.

Gjørup CA, Hendel HW, Pilegaard RK, Willert CB, Hölmich LR. Routine X-ray of the chest is not justified in staging of cutaneous melanoma patients. Dan Med J 2016; 63(12): A5317.

Saito H, Iwabuchi K, Fusaki N, Ito F. Generation of induced pluripotent stem cells from human melanoma tu-mor-infiltrating lymphocytes. J Vis Exp 2016; (117): e54375. doi: 10.3791/54375.

Xiao J, Zhang G, Li B, Wu Y, Liu X, et al. Dioscin aug-ments HSV-tk-mediated suicide gene therapy for mela-noma by promoting connexin-based intercellular com¬m-unication. Oncotarget 2016. In Press. doi: 10.18632/ oncotarget.13655.

Koller KM, Mackley HB, Liu J, Wagner H, Talamo G, et al. Improved survival and complete response rates in patients with advanced melanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone. Cancer Biol Ther 2016. In Press. doi: 10.1080/15384047. 2016.1264543.

Lasithiotakis K, Zoras O. Metastasectomy in cutaneous melanoma. Eur J Surg Oncol 2016. In Press. doi: 10.1016/j.ejso.2016.11.001.

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