Acantholytic squamous cell carcinoma: Pathological study of three cases in Ecuador
Abstract
Adenoid squamous cell carcinoma is an uncommon histopathological variant of squamous cell carcinoma characterized by acantholysis of tumor cells creating pseudolumina and the appearance of glandular differentiation. It is also known as pseudoglandular, pseudoangiosarcomatous, adenoid, epithelioma dyskeratoticum, or adenoacanthoma. In this article, we describe and analyze three cases of acantholytic cell carcinoma. The purpose is to verify if the data of our cases can be validated with scientific information. All our cases presented lesions in the face, and in one of them the developed tumor on the skin showed actinic keratosis. The other two tumors were located in the right side of the face, and both were big: the bigger tumor was approximately 8 × 4 cm and the other one with a size of 6 × 2.5 cm. Due to the size and location, they were both send to the oncologist for treatment. One of our cases showed metatypical carcinomas accompanied by acantholytic variant of squamous cell carcinoma. None of our cases presented metastasis. The histopathological finding were keratinized squamous tumor cell type, adenoid structures with round spaces with a defined wall of at least one-cell width, and spaces with isolated or group of dyskeratotic cells.
References
Lever WF. Adenoacanthoma of sweat glands. Arch Derm Syphilol 1947; 56(2): 157–171. doi: 10.1001/archderm.1947.01520080017002.
Driemel O, Müller-Richter UD, Hakim SG, Bauer R., Berndt A, et al. Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma. Head Face Med 2008; 4: 17. doi: 10.1186/1746-160X-4-17
Yu R, Gohla G, Alowami S. Pseudoglandular squamous cell carcinoma. Cutis 2015; 95(2): 68, 104–106.
Eusebi V, Lamovec J, Cattani MG, Fedeli F, Millis RR. Acantholytic variant of squamous-cell carcinoma of the breast. Am J Surg Pathol 1986; 10(2): 855–861. doi: 10.1097/00000478-198612000-00004.
Lasser A, Cornog JL, Morris JM. Adenoid squamous cell carcinoma of the vulva. Cancer 1974; 33(1): 224–227. doi: 10.1002/1097-0142(197401)33:1<224::AID-CNCR2820330133>3.0.CO;2-6.
Watanabe K, Mukawa A, Miyazaki K, Tsukahara K. Adenoid squamous cell carcinoma of the penis. Report of a surgical case clinically manifested with rapid lung metastasis. Acta Pathol Jpn 1983; 33(6): 1243–1250. doi: 10.1111/j.1440-1827.1983.tb02169.x.
Mauriello JA Jr, Abdelsalam A, McLean IW. Adenoid squamous carcinoma of the conjunctiva-a clinicopathological study of 14 cases. Br J Ophthalmol 1997; 81(11): 1001–1005. doi: 10.1136/bjo.81.11.1001.
Zaatari GS, Santoianni RA. Adenoid squamous cell carcinoma of the nasopharynx and neck region. Arch Pathol Lab Med 1986; 110(6): 542–546.
Papadopoulou E, Tosios KI, Nikitakis N, Papadogeorgakis N, Sklavounou-Andrikopoulou A. Acantholytic squamous cell carcinoma of the gingiva: Report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109(6): e67–e71. doi: 10.1016/j.tripleo.2010.01.019.
Lever WF. Adenoacanthoma of sweat glands. Archives of Dermatol and Syphil 1974; 57: 157–171.
Nappi O, Wick MR, Pettinato G, Ghiselli RW, Swanson PE. Pseudovascular adenoid squamous cell carcinoma of the skin. A neoplasm that may be mistaken for angiosarcoma. Am J Surg Pathol 1992; 16(5): 429–438. doi: 10.1097/00000478-199205000-00001.
Ball E, de Kok E, Tirado M, Lista MT. (Spanish) [Acantholytic pseudoglandular squamous cell cancer. Clinico-pathologic study of 36 cases and bibliographic review]. Dermatol Venez 2012; 50(1): 449–457.
Sajin M, Hodorogea Prisăcaru A, Luchian MC, Pătraşcu OM, Dumitru A, et al. Acantholytic squamous cell carcinoma: Pathological study of nine cases with review of literature. Rom J Morphol Embryol 2014; 55(2): 279–283.
Motley R, Kersey P, Lawrence C; British Association of Dermatologists; British Association of Plastic Surgeons, et al. Multiprofessional guidelines for the management of the patient with primary cutaneous squamous cell carcinoma. Br J Dermatol 2012; 146: 18–25. doi: 10.1046/j.0007-0963.2001.04615.x.
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