Application of facial fat injections
Abstract
Autologous fat has become an ideal filler material due to its easy acquisition, good compatibility and no foreign body sensation after transplantation. In recent years, autologous fat has been widely used in facial rejuvenation or repair and reconstruction, and achieved satisfactory results, which is also in line with the currently advocated minimally invasive treatment direction. Autologous fat transplantation mainly includes fat extraction, separation, transplantation and postoperative treatment, each of which can affect the activity of fat particles and/or fat retention rate after transplantation. In this paper, the application of autologous fat in facial rejuvenation or reconstruction is described in detail.
References
Coleman SR, Katzel EB. Fat grafting for facial filling and regeneration. Clin Plast Surg 2015; 42(3): 289–300. doi: 10.1016/j.cps.2015.04.001.
Peer LA. The neglected free fat graft. Plast Reconstr Surg (1946) 1956; 18(4): 233–250. doi: 10.1097/00006534-195610000-00001.
Klein JA. Tumescent technique for regional anesthesia permits lidocaine doses of 35 mg/kg for liposuction. J Dermatol Surg Oncol 1990; 16(3): 248–263. doi: 10.1111/j.1524-4725.1990.tb03961.x.
Coleman SR. Structural fat grafting. Aesthet Surg J 1998; 18(5): 386–388.
Xie Y, Zheng D, Liu K, Gu B, Li Q. Integrated autologous fat graft in face recontouring. Chinese Journal of Plastic Surgery 2010; 26(3): 178–181. doi: 10.3760/cma.j.issn.1009-4598.2010.03.006.
Pu LLQ. Fat grafting for facial rejuvenation and contouring: A rationalized approach. Ann Plast Surg 2018; 65: S102–S108. doi: 10.1097/SAP.0000000000001326.
Chou CK, Lee SS, Lin TY, Huang YH, Takahashi H, et al. Micro–autologous Fat transplantation (MAFT) for forehead volumizing and contouring. Aesthetic Plast Surg 2017; 41(4): 845–855. doi: 10.1007/s00266-017-0883-2.
Padoin AV, Braga-Silva J, Martins P, Rezende K, Rezende ARR, et al. Sources of processed lipoaspirate cells:influence of donor site on cell concentration. Plast Reconstr Surg 2008; 122(2): 614–618. doi: 10.1097/PRS.0b013e31817d5476.
Rohrich RJ, Sorokin ES, Brown SA. In search of improved fat transfer viability: A quantitative analysis of the role of centrifugation and harvest site. Plast Reconstr Surg 2004; 113(1): 391–395. doi: 10.1097/01.PRS.0000097293.56504.00.
Ullmann Y, Shoshani O, Fodor A, Ramon Y, Carmi N, et al. Searching for the favorable donor site for fat injection: In vivo study using the nude mice model. Dermatol Surg 2005; 31(10): 1304–1307. doi: 10.1111/j.1524-4725.2005.31207.
Li K, Gao J, Zhang Z, Li J, Cha P, et al. Selection of donor site for fat grafting and cell isolation. Aesthetic Plast Surg 2013; 37(1): 153–158. doi: 10.1007/s00266-012-9991-1.
Moore JH Jr, Kolaczynski JW, Morales LM, Considine RV, Pietrzkowski Z, et al. Viability of fat obtained by syringe suction lipectomy: Effects of local anesthesia with lidocaine. Aesthetic Plast Surg 1995; 19(4): 335–339. doi: 10.1007/BF00451659.
Livaoglu M, Buruk CK, Uraloglu M, Ersöz S, Livaogğlu A, et al. Effects of lidocaine plus epinephrine and prilocaine on autologous fat graft survival. J Craniofac Surg 2012; 23(4): 1015–1018. doi: 10.1097/SCS.0b013e31824e7302.
Shoshani O, Berger J, Fodor L, Ramon Y, Shupak A, Kehat I, et al. The effect of lidocaine and adrenaline on the viability of injected adipose tissue—An experimental study in nude mice. J Drugs Dermatol 2005; 4(3): 311–316. PMID: 15898286.
Agostini T, Lazzeri D, Pini A, Marino G, Li Q, et al. Wet and dry techniques for structural fat graft harvesting: Histomorphometric and cell viability assessments of lipoaspirated samples. Plast Reconstr Surg 2012; 130(2): 331e–339e. doi: 10.1097/PRS.0b013e3182589f76.
Leong DT, Hutmacher DW, Chew FT, Lim TC. Viability and adipogenic potential of human adipose tissue processed cell population obtained from pump-assisted and syringe-assisted liposuction. J Dermatol Sci 2005; 37(3): 169–176. doi: 10.1016/j.jdermsci.2004.11.009.
Smith P, Adams WP Jr, Lipschitz AH, Chau B, Sorokin E, et al. Autologous human fat grafting: Effect of harvesting and preparation techniques on adipocyte graft survival. Plast Reconstr Surg 2006; 117(6): 1836–1844. doi: 10.1097/01.prs.0000218825.77014.78.
Gupta R, Brace M, Taylor SM, Bezuhly M, Hong P. In search of the optimal processing technique for fat grafting. J Craniofac Surg 2015; 26(1): 94–99. doi: 10.1097/SCS.0000000000001259.
Ramon Y, Shoshani O, Peled IJ, Gilhar A, Carmi N, et al. Enhancing the take of injected adipose tissue by a simple method for concentrating fat cells. Plast Reconstr Surg 2005; 115(1): 197–201. doi: 10.1097/01.PRS.0000145713.49152.77.
Kurita M, Matsumoto D, Shigeura T, Sato K, Gonda K, et al. Influences of centrifugation on cells and tissues in liposuction aspirates: Optimized centrifugation for lipotansfer and cell isolation. Plast Reconstr Surg 2008; 121(3): 1033–1041. doi: 10.1097/01.prs.0000299384.53131.87.
Qiu L, Su Y, Zhang D, Song Y, Liu B, et al. Identification of the centrifuged lipoaspirate fractions suitable for postgrafting survival. Plast Reconstr Surg 2016; 137(1): 67e–76e. doi: 10.1097/PRS.0000000000001883.
Coleman SR. Facial recontouring with lipostructure. Clin Plast Surg 1997; 24(2): 347–367. doi: 10.1016/S0094-1298(20)31069-5.
Yoshimura K, Shigeura T, Matsumoto D, Sato T, Takaki Y, et al. Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates. J Cell Physiol 2006; 208(1): 64–76. doi: 10.1002/jcp.20636.
Deng J, Zhang Q, Cao W, Liu L, Jiang Z, et al. Clinical Application of Autologous Fat Grafting for Facial Contour Improvement and Facial Rejuvenation. Journal of Tissue Engineering and Reconstructive Surgery 2015; 11(6): 365–369. doi: 10.3969/j.issn.1673-0364.2015.06.005.
Xie Y, Li Q, Zheng D, Lei H, Pu LLQ, et al. Correction of hemifacial atrophy with autologous fat transplantation. Ann Plast Surg 2007; 59(6): 645–653. doi: 10.1097/SAP.0b013e318038fcb7.
Wang G, Ren Y, Cao W, Yang Y, Li S. Liposculpture and fat grafting for aesthetic correction of the gluteal concave deformity associated with the multiple intragluteal injection of penicillin in childhood. Aesth Plast Surg 2013; 37(1): 39–45. doi: 10.1007/s00266-012-9997-8.
Huang RL, Xie Y, Wang W, Tanja H, Zhou J, et al. Anatomical study of temporal fat compartments and its clinical application for temporal fat grafting. Aesthet Surg J 2017; 37(8): 855–862. doi: 10.1093/asj/sjw257.
Boureaux E, Chaput B, Bannani S, Herlin C, De Runz A, et al. Eyelid fat grafting: Indications, operative technique and complications; a systematic review. J Craniomaxillofac Surg 2016; 44(4): 374–380. doi: 10.1016/j.jcms.2015.12.013.
Rohrich RJ, Pessa JE. The fat compartments of the face: Anatomy and clinical implications for cosmetic surgery. Plast Reconstr Surg 2007; 119(7): 2219–2227. doi: 10.1097/01.prs.0000265403.66886.54.
Wang W, Xie Y, Huang RL, Zhou J, Tanja H, et al. Facial contouring by targeted restoration of facial fat compartment volume: The midface. Plast Reconstr Surg 2017; 139(3): 563–572. doi: 10.1097/PRS.0000000000003160.
Tonnard P, Verpaele A, Peeters G, Hamdi M, Cornelissen M, et al. Nanofat grafting: Basic research and clinical applications. Plast Reconstr Surg 2013; 132(4): 1017–1026. doi: 10.1097/PRS.0b013e31829fe1b0.
Yao Y, Dong Z, Liao Y, Zhang P, Ma J, et al. Adipose extracellular Matrix/Stromal vascular fraction gel: A novel adipose Tissue–Derived injectable for stem cell therapy. Plast Reconstr Surg 2017; 139(4): 867–879. doi: 10.1097/PRS.0000000000003214.
Yao Y, Cai J, Zhang P, Liao Y, Yuan Y, et al. Adipose stromal vascular fraction gel grafting: A new method for tissue volumization and rejuvenation. Dermatol Surg 2018; 44(10): 1278–1286. doi: 10.1097/DSS.0000000000001556.
Zhang Y, Cai J, Zhou T, Yao Y, Dong Z, et al. Improved long-term volume retention of stromal vascular fraction gel grafting with enhanced angiogenesis and adipogenesis. Plast Reconstr Surg 2018; 141(5): 676e–686e. doi: 10.1097/PRS.0000000000004312.
Rigotti G, Marchi A, Galie M, Baroni G, Benati D, et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: A healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg 2007; 119(5): 1409–1422. doi: 10.1097/01.prs.0000256047.47909.71.
Coleman SR. Structural fat grafting: More than a permanent filler. Plast Reconstr Surg 2006; 118(3 Suppl): 108S–120S. doi: 10.1097/01.prs.0000234610.81672.e7.
Fredman R, Katz AJ, Hultman CS. Fat grafting for burn, traumatic, and surgical scars. Clin Plast Surg 2017; 44(4): 781–791. doi: 10.1016/j.cps.2017.05.009.
Negenborn VL, Groen JW, Smit JM, Niessen FB, Mullender MB. The use of autologous fat grafting for treatment of scar tissue and scar-related conditions: A systematic review. Plast Surg Nurs 2016; 36(3): 131–143. doi: 10.1097/PSN.0000000000000155.
Mojallal A, Lequeux C, Shipkov C, Breton P, Foyatier J-L, et al. Improvement of skin quality after fat grafting: Clinical observation and an animal study. Plast Reconstr Surg 2009; 124(3): 765–774. doi: 10.1097/PRS.0b013e3181b17b8f.
Ducic I, Moriarty M, Al-Attar A. Anatomical variations of the occipital nerves: Implications for the treatment of chronic headaches. Plast Reconstr Surg 2009; 123(3): 859–863. doi: 10.1097/PRS.0b013e318199f080.
Negenborn VL, Groen JW, Smit JM, Niessen FB, Mullender MB. The use of autologous fat grafting for treatment of scar tissue and scar-related conditions: A systematic review. Plast Reconstr Surg 2016; 137(1): 31e–43e. doi: 10.1097/PRS.0000000000001850.
Brongo S, Nicoletti GF, La Padula S, Mele CM, D'Andrea F. Use of lipofilling for the treatment of severe burn outcomes. Plast Reconstr Surg 2012; 130(2): 374e–376e. doi: 10.1097/PRS.0b013e3182590387.
Klinger M, Caviggioli F, Klinger FM, Giannasi S, Bandi V, et al. Autologous fat graft in scar treatment. J Craniofac Surg 2013; 24(5): 1610–1615. doi: 10.1097/SCS.0b013e3182a24548.
Zhang Q, Liu LN, Yong Q, Deng JC, Cao WG. Intralesional injection of adipose-derived stem cells reduces hypertrophic scarring in a rabbit ear model. Stem Cell Res Ther 2015; 6(2): 145–155. doi: 10.1186/s13287-015-0133-y.
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