Effect of cryotherapy and ALA-PDT therapy on skin cancer

Zhi Zhong, Hongliu Deng, Wei Liu


Objective: to study the effect of cryotherapy and ALA-PDT therapy on skin cancer. Methods: this study selected 60 patients with skin cancer admitted to Ankang People’s Hospital of Shaanxi Province from January 2014 to December 2019. According to different treatment methods, 30 patients treated with ALA-PDT were included in the control group, while 30 patients treated with cryotherapy combined with ALA-PDT were included in the observation group. The total effective rate, pain score, surgical trauma area, incidence of adverse reactions and total satisfaction rate of appearance were compared between the two groups. Results: the treatment efficiency of the observation group was 96.7%, which was higher than that of the control group (73.3%), with a statistically significant difference (P < 0.05). The pain score in the observation group was (4.12 ± 1.03), higher than that of the control group (3.45 ± 0.86), and the surgical trauma area was (1.26 ± 0.04) cm2, lower than that of the control group (1.39 ± 0.05) cm2, with a statistically significant difference (P < 0.05). The difference was statistically significant (all P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Besides, the total satisfaction rate of the observation group was 93.3%, which was higher than that of the control group (66.7%), and the difference was statistically significant (P < 0.05). Conclusion: Cryotherapy combined with ALA-PDT therapy are clinically effective in the treatment of skin cancer, with less invasive surgical areas and higher patient satisfaction with appearance. However, the pain score is relatively higher. Therefore, the appropriate treatment can be clinically considered in a comprehensive manner.


cryotherapy; ALA-PDT therapy; cutaneous tumor; effect

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